The control design of open-cycle desiccant systems involves three operation modes (ventilation, evaporative cooling and desiccant cooling) and two control parameters (regeneration temperature and air‘ ow rate) to match the cooling load. Speci” c HVAC component models have been added to SIMBAD library to run in Matlab/SimulinkÒ environment. The control strategy is de” ned using State‘ owÒprogram which is a user-friendly graphical tool. The whole simulation tool is used to set an adapted control strategy. The energy consumption and performance of the desiccant system are investigated for different cases of building loads, thermal inertia and climate during the cooling period.